Recent Progress on Apoptotic Activity of Triazoles

Cikla-Suzgun P., Kucukguzel S. G.

CURRENT DRUG TARGETS, cilt.22, sa.16, ss.1844-1900, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 22 Sayı: 16
  • Basım Tarihi: 2021
  • Doi Numarası: 10.2174/1389450122666210208181128
  • Dergi Adı: CURRENT DRUG TARGETS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1844-1900
  • Anahtar Kelimeler: Apoptosis, triazole, cancer, caspase-8, caspase-3, Bcl-2, cytochrome C, HEAT-SHOCK FACTOR-1, BIOLOGICAL EVALUATION, ANTICANCER ACTIVITY, CANCER-CELLS, ANTITUMOR-ACTIVITY, BETULINIC ACID, LUNG-CANCER, AROMATASE INHIBITORS, CYTOTOXIC ACTIVITY, CARCINOMA CELLS
  • Marmara Üniversitesi Adresli: Evet

Özet

Apoptosis is often called programmed cell death and is defined as a self-directed cell destruction process. It is different from necrosis due to the activation of caspases during this process. Apoptosis is directly related to cancer progression and plays a vital role in carcinogenesis; all cytotoxic drugs and radiation therapy programs initiate apoptosis in tumor cells. Today, studies show that heterocyclic compounds that contain triazole functionality have anticancer activities; triazoles are 5 membered rings, which contain two carbon and three nitrogen atoms. Therefore, many researchers have synthesized these small active compounds as target structures and evaluated their apoptotic activities. The present review describes recent medicinal aspects of triazoles as anticancer agents that have been reported during the past few years. We hope that the bioactivity of triazole derivatives will be beneficial for the rational design of a new generation of small molecule drugs.