Behcet's disease in patients with chronic myelogenous leukemia: Possible role of interferon-alpha treatment in the occurrence of Behcet's symptoms

BudakAlpdogan T., Demircay Z., Alpdogan O., DİRESKENELİ R. H. , Ergun T. , Bayik M., ...More

ANNALS OF HEMATOLOGY, vol.74, no.1, pp.45-48, 1997 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 74 Issue: 1
  • Publication Date: 1997
  • Doi Number: 10.1007/s002770050255
  • Title of Journal : ANNALS OF HEMATOLOGY
  • Page Numbers: pp.45-48
  • Keywords: Behcet's disease, chronic myelogenous leukemia, pathergy reaction, adverse effect, alpha-interferon, CHRONIC MYELOID-LEUKEMIA, PROGENITOR CELLS, THERAPY


Two patients with chronic myelogenous leukemia (CML) who developed characteristic features of Behcet's disease (ED) during alpha-interferon (IFN-alpha) treatment and another patient who had a diagnosis of ED preceding CML are presented. In the first two patients, features of ED appeared 6 months after the initiation of IFN-alpha treatment; they included recurrent oral aphthae, genital ulceration, arthritis, folliculitis, and a positive skin pathergy test. The third patient, however, had a diagnosis of Behcet's disease 4 years before diagnosis of Philadelphia-positive CML. We prospectively examined the skin pathergy reaction in a group of patients with CML, multiple myeloma, and hairy cell leukemia both before and after IFN-alpha treatment and found two additional patients with CML who developed a positive skin pathergy test following IFN-alpha treatment.