Once-Weekly Somapacitan vs Daily GH in Children With GH Deficiency: Results From a Randomized Phase 2 Trial

Sävendahl, Lars; Battelino, Tadej; Brod, Meryl; Rasmussen, Michael; Horikawa, Reiko; Juul, Rasmus; Saenger, Paul; Furthner, Dieter; Piringer, Bettina; Auer-Hackenberg, Lorenz; Schmitt, Klaus; Reitmayr, Marlene; Bronstein, Marcello; Lima, Francisco; Wabitsch, Martin; Posovszky, Carsten; Bottcher, Volker; Mann, Alexander; Hershkovitz, Eli; Haim, Alon; Lowenthal, Neta; Hamiel, Orit; Levin, Sharon; Mazor-Aronovitch, Kineret; Ben-Ami, Michal; Shraga, Yael; Modan, Dalit; Gruber, Noah; Phillip, Moshe; Lebenthal, Yael; Tenenbaum, Ariel; Eliakim, Alon; Dror, Nitzan; Haviv, Ruby; Zuckerman-Levin, Nehama; Shehadeh, Naim; Givon, Liav; Elemy, Ameer; Marji, Miriam; Gepstein, Vardit; Praveen, V.P.; Aswin, P.; Abraham, Nithiya; Khadgawat, Rajesh; Gupta, Yashdeep; Khadilkar, Vaman; Khadilkar, Anuradha; Lad, Sagar; Naiki, Yasuhiro; Ogiwara, Yasuko; Chiba, Yuta; Fujisawa, Yusuke; Terada, Yumiko; Yoshida, Tomoko; Kinjo, Kenichi; Tsukamura, Atsushi; Ida, Shinobu; Etani, Yuri; Shoji, Yasuko; Kawai, Masanobu; Nakajima, Hisakazu; Mori, Jun; Fukuhara, Shota; Shigehara, Keiichi; Morimoto, Hidechika; Tsuma, Yusuke; Kawabe, Yasuhiro; Ota, Takeshi; Kashimada, Kenichi; Nakagawa, Ryuichi; Tsuji, Atsumi; Nomura, Risa; Takasawa, Kei; Yamauchi, Takeru; Ishii, Kanako; Toda, Naoko; Ohkubo, Kazuhiro; Yorifuji, Tohru; Hosokawa, Yuki; Kawakita, Rie; Hashimoto, Yukiko; Sakakibara, Azumi; Higuchi, Shinji; Soneda, Shun; Ogushi, Kenichiro; Yatsuga, Shuichi; Koga, Yasutoshi; Matsumoto, Takako; Kitamura, Miyuki; Nergardh, Ricard; Tansek, Mojca; Turan, SERAP; Bereket, ABDULLAH; Atay, Zeynep; Akbarzade, Azad; Bolshova, Olena; Tronko, Mykola; Vyshnevskaya, Olga; Sprynchuk, Natalia; Lukashuk, Iryna; Muz, Natalia; Marchenko, Tatyana; Chorna, Nataliya; Konovalova, Mariana; Zelinska, Liliya; Silverman, Lawrence; Cerame, Barbara; Cheruvu, Sunita; Chin, Daisy; Ebner-Lyon, Laurie; Fox, Marie; Nicolette-Gentile, Marianna; Sabanosh, Kristin; Starkman, Harold; Marshall, Ian; Gangat, Mariam; Balachandar, Sadana; Backeljauw, Philippe; Dauber, Andrew; Tyzinski, Leah; Siliezar, Luis; Velasco, Jacqueline; Ross, Judith; Bardsley, Martha; Kowal, Karen; Kletter, Gad; Frazier, Britney; Garrison, Kathryn

doi:10.1210/clinem/dgz310

Once-Weekly Somapacitan vs Daily GH in Children With GH Deficiency: Results From a Randomized Phase 2 Trial

Atıf İçin Kopyala

Sävendahl L., Battelino T., Brod M., Rasmussen M. H., Horikawa R., Juul R. V., ...Daha Fazla

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, cilt.105, sa.4, 2020 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 105 Sayı: 4
Basım Tarihi: 2020
Doi Numarası: 10.1210/clinem/dgz310
Dergi Adı: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, Chemical Abstracts Core, CINAHL, EMBASE, Food Science & Technology Abstracts, Gender Studies Database, MEDLINE, Veterinary Science Database
Anahtar Kelimeler: growth hormone, growth hormone deficiency, growth hormone replacement therapy, long-acting growth hormone, somapacitan, treatment burden, GROWTH-HORMONE, REFERENCE INTERVALS, IGF-I, INSULIN, MULTICENTER, POSSESSES, SAFETY, ANALOG
Marmara Üniversitesi Adresli: Evet

Özet

Context: Daily growth hormone (GH) injections can be burdensome for patients and carers. Somapacitan is a long-acting, reversible albumin-binding GH derivative in development for once-weekly administration in patients with growth hormone deficiency (GHD).