Dental follicle mesenchymal stem cells regulate responses in sepsis

Gül F., GENÇ D., ARSLANTAŞ M. K., Zibandeh N., Topçu L., AKKOÇ T., ...Daha Fazla

MARMARA MEDICAL JOURNAL, cilt.33, sa.1, ss.7-16, 2020 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.5472/marumj.681996
  • Dergi Adı: MARMARA MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.7-16
  • Anahtar Kelimeler: Sepsis, Septic shock, Dental follicle mesenchymal stem cells, Immunomodulation, HUMAN BONE-MARROW, INTERFERON-GAMMA, INDUCED IMMUNOSUPPRESSION, MECHANISMS, CYTOKINES
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective: Sepsis-induced immune alterations are associated with secondary infections and increased risk of death. The use of mesenchymal stern cells (MSCs) has been described as a novel therapeutic strategy. We evaluated the immunomodulatory effects of human dental follicle (DF-MSCs) on lymphocytes of sepsis and septic shock patients.