Synthesis of 3-amino-4-hydroxy coumarin and dihydroxy-phenyl coumarins as novel anticoagulants


DANIŞ Ö., Yuce-Dursun B., Gunduz C., OGAN A., ŞENER G., Bulut M., ...More

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, vol.60, no.10, pp.617-620, 2010 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 10
  • Publication Date: 2010
  • Journal Name: ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.617-620
  • Keywords: Anticoagulants, 3-Amino-4-hydroxy coumarin, 7,8-Dihydroxy-3-(4-methyl-phenyl)coumarin, 5,7-Dihydroxy-4-phenyl coumarin, Prothrombin time, Warfarin, ORAL ANTICOAGULANTS, DERIVATIVES, PHARMACOGENETICS
  • Marmara University Affiliated: Yes

Abstract

Natural and synthetic coumarin derivatives have been shown to possess several beneficial pharmacological effects. The anticoagulation and antithrombotic activities of the 4-hydroxy coumarin derivatives are well known. In this study, besides the 4-hydroxy substituent phenyl and p-methylphenyl derivatives were synthesized and confirmed on the basis of their spectral data. 3-Amino-4-hydroxy coumarin, 5,7-dihydroxy-4-phenyl coumarin and 7,8-dihydroxy-3-(4-methyl-phenyl)coumarin were tested in rats to determine whether they had any effect on vitamin K inhibition by investigating the prothrombin time (PT). PT values of coumarin derivatives were compared with those of warfarin (CAS 81-81-2), which is the most commonly used anticoagulant. 7,8-Dihydroxy-3-(4-methylphenyl) coumarin increased PT when compared to saline treated control group and other coumarins synthesized, 3-amino-4-hydroxy coumarin and 5,7-dihydroxy-4-phenyl coumarin.