PIK3CA and TP53 MUTATIONS and SALL4, PTEN and PIK3R1 GENE EXPRESSION LEVELS in BREAST CANCER


DİRİCAN E., ERBARUT SEVEN İ. , KAYA H. , UĞURLU M. Ü. , PEKER EYÜBOĞLU İ. , GÜLLÜOĞLU M. B. , ...More

TURKISH JOURNAL OF BIOCHEMISTRY, vol.45, pp.515-523, 2020 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 45
  • Publication Date: 2020
  • Doi Number: 10.1515/tjb-2019-0137
  • Title of Journal : TURKISH JOURNAL OF BIOCHEMISTRY
  • Page Numbers: pp.515-523
  • Keywords: Breast cancer, PI3K, PIK3CA, HRM, Candidate genes, CELL-PROLIFERATION, ASSOCIATION

Abstract

Objective: A high frequency of PI3K signalling pathway abnormalities and TP53 mutations are critical in the development and progression of breast cancer (BCa). We aimed to detect PIK3CA and TP53 mutations via an expression analysis of PIK3R1, PTEN and SALL4 and correlate the expression of these genes with clinical parameters of BCa.