Effect of oxidative stress on aorta and tibia osteoprotegerin gene expression in ovariectomized rats


AYDIN H., DEYNELİ O., YAVUZ D. , YÜKSEL M. , TARÇIN Ö. , YAZICI D., ...More

MINERVA ENDOCRINOLOGICA, vol.36, no.2, pp.107-115, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 2
  • Publication Date: 2011
  • Title of Journal : MINERVA ENDOCRINOLOGICA
  • Page Numbers: pp.107-115
  • Keywords: Ovariectomy, Osteoprotegerin, Oxidative stress, HORMONE REPLACEMENT THERAPY, BONE-MINERAL DENSITY, KAPPA-B LIGAND, NITRIC-OXIDE, ESTROGEN DEFICIENCY, VASCULAR CALCIFICATION, RECEPTOR ACTIVATOR, ENDOTHELIAL DYSFUNCTION, POSTMENOPAUSAL WOMEN, OSTEOPOROSIS

Abstract

Aim. Atherosclerosis and osteoporosis share some common pathophysiological pathways. Increase in oxidative stress and activation of cytokines that increase osteoclastogenesis were reported in postmenopausal period. The aim of this study was to determine the link between these two states.