Protective and therapeutic effects of resveratrol on acetic acid-induced gastric ulcer


Solmaz A., Sener G., ÇETİNEL Ş. , Yueksel M., Yegen C. , YEGEN B.

Free Radical Research, vol.43, no.6, pp.594-603, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 6
  • Publication Date: 2009
  • Doi Number: 10.1080/10715760902977424
  • Title of Journal : Free Radical Research
  • Page Numbers: pp.594-603
  • Keywords: Resveratrol, ulcer healing, oxidative stress, NATURAL POLYPHENOLIC COMPOUND, NITRIC-OXIDE SYNTHASE, TUMOR-NECROSIS-FACTOR, REACTIVE OXYGEN, RED WINE, OXIDATIVE STRESS, INDUCED TOXICITY, FREE-RADICALS, LUNG INJURY, INFLAMMATION

Abstract

Sprague Dawley rats of both sexes were injected with either saline or RVT (10 mg/kg) either before or after acetic acid ulcer induction and decapitated 3, 5 or 10 days after ulcer. In the saline-treated ulcer groups, macroscopically evident ulcers were observed, while RVT-pretreated or RVT-treated groups had lower macroscopic ulcer scores. Likewise, the microscopic damage scores were lower for the RVT-administered groups. Gastric myeloperoxidase activity, malondialdehyde, collagen and tumour necrosis factor-alpha levels, as well as luminol- and lucigenin-enhanced chemiluminescence levels that were elevated in the saline-administered ulcer groups, were depressed with both RVT-pretreatment and RVT-treatment. Moreover, depleted glutathione levels in the ulcer groups were increased back to control levels by both pre- and post-treatments of RVT. Results demonstrate that resveratrol has both protective and therapeutic effects on oxidative gastric damage by suppressing pro-inflammatory cascades, including the activation of pro-inflammatory cytokines, accumulation of neutrophils and release of oxygen-derived free radicals.