High-fat Diet Enhances Gastric Contractility, but Abolishes Nesfatin-1-induced Inhibition of Gastric Emptying


Ozdemir-Kumral Z. N. , KOYUNCUOĞLU T. , ARABACI TAMER S. , KAYA Ö. T. , Koroglu A. K. , YÜKSEL M. , ...More

JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY, vol.27, no.2, pp.265-278, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.5056/jnm20206
  • Title of Journal : JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
  • Page Numbers: pp.265-278

Abstract

Neither HFD nor NES-1 changed methylcellulose emptying, but NES-1 delayed saline emptying in cannulated ND-rats. Inhibitory effect of NES-1 on gastric emptying in ND-rats was reversed by all antagonists, and abolished in HFD-rats. In HFD-rats, carbachol-induced contractility was enhanced in gastric, but inhibited in ileal strips. HFD increased body weight, while serum triglycerides, alanine transaminase, aspartate aminotransferase, glucose, and levels of malondialdehyde, glutathione, myeloperoxidase activity, and luminolchemiluminescence in hepatic, ileal, and adipose tissues were similar in ND- and HFD-rats, but only lucigenin-chemiluminescence was