Evaluation of the wound healing potential of Aloe vera-based extract of Nerium oleander


Akgün Ölmez S. G. , Aydemir S. , Özkan N. , Yüksel M. , Sardas S.

NORTHERN CLINICS OF ISTANBUL, vol.4, pp.205-212, 2017 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 4
  • Publication Date: 2017
  • Doi Number: 10.14744/nci.2017.94914
  • Title of Journal : NORTHERN CLINICS OF ISTANBUL
  • Page Numbers: pp.205-212
  • Keywords: Anti-inflammatory effect, antioxidant effect, DNA damage, nerium oleander, DOUBLE-STRAND BREAKS, OXIDATIVE STRESS, BURN-INJURY, LIPID-PEROXIDATION, THERMAL-INJURY, SKIN INJURY, DNA-DAMAGE, CHO-CELLS, RATS, ANTIOXIDANT

Abstract

OBJECTIVE: Nerium oleander (Apocynaceae) and Aloe vera (Liliaceae) are among the widely used herbal remedies for treating skin diseases and possess numerous activities such as antibacterial, antiviral, antifungal, and antioxidant. The aim of this study was to investigate the possible wound healing effect of Aloev era-based extract of the N. oleander leaf (NAE-8 (R)) based on its antioxidant, anti-inflammatory, and DNA repair capacity along with histological changes and to compare them with the traditional silver sulfadiazine treatment (SSD).