PTEN loss is not associated with trastuzumab resistance in metastatic breast cancer


Kocar M., Bozkurtlar E. , Telli F., Turhal N. S. , Kaya H. , Kocar H., ...More

JOURNAL OF BUON, vol.19, pp.900-905, 2014 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 19
  • Publication Date: 2014
  • Title of Journal : JOURNAL OF BUON
  • Page Numbers: pp.900-905

Abstract

Purpose: Although the clinical benefits of trastuzumab are well known, intrinsic or acquired resistance is a commonly encountered clinical condition. A potential resistance mechanism is aberrant downstream signal transmission due to loss of phosphatase and tensine homologue (PTEN). This study investigated the relationship between trastuzumab response and loss of PTEN in metastatic breast cancer patients.