Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers


Mohamady Hussein M. A. , Guler E., RAYAMAN E. , ÇAM M. E. , ŞAHİN A. , Grinholc M., ...More

CARBOHYDRATE POLYMERS, vol.270, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 270
  • Publication Date: 2021
  • Doi Number: 10.1016/j.carbpol.2021.118373
  • Title of Journal : CARBOHYDRATE POLYMERS
  • Keywords: Silver nanoparticles, Chitosan, Phenytoin, Dual-drug delivery, Core-shell nanofibers, SILVER NANOPARTICLES, WOUND DRESSINGS, CONTROLLED-RELEASE, COMPOSITE, FABRICATION, ALGINATE, FIBERS

Abstract

Dual-drug delivery systems were constructed through coaxial techniques, which were convenient for the model drugs used the present work. This study aimed to fabricate core-shell electrospun nanofibrous membranes displaying simultaneous cell proliferation and antibacterial activity. For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer. The morphology, chemical composition, mechanical and thermal properties of the nanofibrous membranes were characterized by FESEM/STEM, FTIR and DSC. The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs) showed more controlled Ph release than PVA/PCL-Ph NFs. There was notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs. The proposed core-shell PVA/PCL NFs represent promising scaffolds for tissue regeneration and wound healing by the effective dual delivery of phenytoin and Ag-CS NPs.