Developments of 3D polycaprolactone/beta-tricalcium phosphate/collagen scaffolds for hard tissue engineering

Aydogdu M. O., Mutlu B., Kurt M., İnan A. T., Kuruca E S., Erdemir G., ...More

Journal of the Australian Ceramic Society, vol.55, no.3, pp.849-855, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 3
  • Publication Date: 2019
  • Doi Number: 10.1007/s41779-018-00299-y
  • Journal Name: Journal of the Australian Ceramic Society
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.849-855
  • Keywords: Biomaterials, Biomedical engineering, Additive manufacturing, Hard tissue scaffolds, NANOFIBROUS SCAFFOLD
  • Marmara University Affiliated: Yes


3D bioprinting provides an innovative strategy to fabricate a new composite scaffold material consisted in a porous and rough structure with using polycaprolactone (PCL), beta-tricalcium phosphate (β-TCP), and collagen as a building block for tissue engineering. We investigated the optimization of the scaffold properties based on the β-TCP concentration using 3D bioprinting method. Computer-aided drawing was applied in order to digitally design the scaffolds while instead of solid filaments, materials were prepared as a blend solution and controlled evaporation of the solvent during the bioprinting was enabled the proper solidification of the scaffolds, and they were successfully produced with well-defined porous structure. This work demonstrated the feasibility of complex PCL/β-TCP/collagen scaffolds as an alternative in the 3D bioprinting engineering to the fabrication of porous scaffolds for tissue engineering.