A Network-Based Cancer Drug Discovery: From Integrated Multi-Omics Approaches to Precision Medicine

TURANLI B., Karagoz K., Gulfidan G., Sinha R., Mardinoglu A., ARĞA K. Y.

CURRENT PHARMACEUTICAL DESIGN, cilt.24, sa.32, ss.3778-3790, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 24 Sayı: 32
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1381612824666181106095959
  • Dergi Adı: CURRENT PHARMACEUTICAL DESIGN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3778-3790
  • Anahtar Kelimeler: Drug discovery, drug repositioning, network-based, precision medicine, breast cancer, pharmaco-omics, NEGATIVE BREAST-CANCER, COMPREHENSIVE MOLECULAR PORTRAITS, PROTEIN-PROTEIN INTERACTIONS, THERAPEUTIC TARGET DATABASE, GENE-COEXPRESSION NETWORK, PLASMA MANNOSE LEVELS, WEB SERVER, INTERACTION PREDICTION, METABOLIC NETWORK, SYSTEMS BIOLOGY
  • Marmara Üniversitesi Adresli: Evet

Özet

A complex framework of interacting partners including genetic, proteomic, and metabolic networks that cooperate to mediate specific functional phenotypes drives human biological processes. Recent technological and analytical advances in "omic" sciences allow the identification and elucidation of reprogramming biological functions in response to perturbations in cells and tissues. To understand such a complex system, biological networks are generated to reduce the complexity into relatively simple models, and the integration of these molecular networks from different perspectives is implemented for a holistic interpretation of the entire system. Ultimately, network-based methods will effectively facilitate the development and improvement of precision medicine by directing therapies based on the underlying biology of a given patient's disease.