Assessment of cardiovascular findings in FMF related amyloid patients Ailevi akdeniz ateşine ikincil gelişen amiloidozda kardiyovasküler bulguların değerlendirilmesi
Medeniyet Medical Journal, cilt.33, sa.3, ss.149-157, 2018 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 33 Sayı: 3
- Basım Tarihi: 2018
- Doi Numarası: 10.5222/mmj.2018.05826
- Dergi Adı: Medeniyet Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.149-157
- Anahtar Kelimeler: CIMT, E/A ratio, FMF, Secondary amyloidosis
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Marmara Üniversitesi Adresli: Hayır
Özet
© 2018, Logos Medical Publishing. All rights reserved.Aim: The aim of the study is to compare cardiovascular findings in amyloidosis developed secondary to familial Mediterranean fever (FMF), with those of patient, and healthy control groups. Method: The study was performed on 32 secondary amyloid patients, 33 FMF patients and 65 healthy control individuals. Left ventricular functions were measured using two-dimensional, M-mode, conventional and tissue Doppler echocardiographic images. Aortic elasticity was analyzed using 2-D, M-mode echocardiographic images. Carotid-intima media thickness (CIMT) was measured using carotid artery B-mode ultrasonography. Results: Age, sex and serum lipids were comparable among groups (p>0.05). Aortic wall elasticity properties were similar between groups (p>0.05). Mitral annular E/A ratios were significantly lower in the amyloid group compared with controls ((p=0.004). CIMT was markedly higher in the amyloid group (p=0.001). In addition, CIMT values was higher in FMF patients than healthy controls (p=0.03). Ejection fraction and left ventricular mass index were similar among groups (p>0.05, for both). Conclusion: These findings suggested that subclinical myocardial involvement may be present in patients who developed amyloidosis secondary to FMF: It is noted that CIMT values were higher in patients with secondary amyloidosis.