Immunohistochemical and Ultrastructural Changes Related To Methylphenidate In Rat Pituitary and Pineal Glands

ELMAS Ç., BAHÇELİOĞLU M., Erdogan D., Gozil R., TAKE KAPLANOĞLU G., Calguner E., ...More

JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, vol.29, no.3, pp.476-493, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 3
  • Publication Date: 2012
  • Journal Name: JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.476-493
  • Keywords: Methylphenidate, dopamine D2 receptor, pituitary gland, pineal gland, in situ nick-end labelling, ultrastructure, CORTICOTROPIN-RELEASING FACTOR, AGE-RELATED-CHANGES, ADULT MALE RATS, ADOLESCENT RATS, NUCLEUS-ACCUMBENS, EXTRACELLULAR DOPAMINE, ENDURING CHANGES, D-AMPHETAMINE, LOCOMOTOR, BRAIN
  • Marmara University Affiliated: No

Abstract

Objective: The presence of a dopaminergic function in pituitary and pineal glands is well known. Methylphenidate (MPH), a widely prescribed psychostimulant for attention deficit/hyperactivity disorder, is an indirect dopamine agonist which could have the capacity of influencing the hypothalamo-neurohypophysial system with the pineal gland. Our aim is to investigate dose-dependent immunohistochemical dopamine 2 expression, possible cell apoptosis and ultrastructural changes of the rat pituitary and pineal gland tissue, to demonstrate possible toxicity of the chronic extended use of the MPH.