Protective effects of resveratrol against acetaminophen-induced toxicity in mice

Sener G., Toklu H., Sehirli A., Velioglu-Ogunc A., Cetinel Ş., Gedik N.

HEPATOLOGY RESEARCH, cilt.35, sa.1, ss.62-68, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 1
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.hepres.2006.02.005
  • Dergi Adı: HEPATOLOGY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.62-68
  • Anahtar Kelimeler: acetaminophen, resveratrol, hepatic, glutathione, TNF-alpha, myeloperoxidase, RED WINE, OXIDATIVE STRESS, REACTIVE OXYGEN, FREE-RADICALS, PROTEIN, INJURY, HEPATOTOXICITY, GLUTATHIONE, MECHANISMS, MELATONIN
  • Marmara Üniversitesi Adresli: Evet

Özet

This investigation elucidates the role of free radicals in acetaminophen (AA)-induced toxicity and the possible protection by resveratrol (RVT). BALB-c mice were injected with a single dose of 900 mg/kg AA to induce toxicity, while RVT administred in a dose of 30 mg/kg i.p. following AA.