Nesfatin-1 ameliorates oxidative bowel injury in rats with necrotizing enterocolitis: The role of the microbiota composition and claudin-3 expression

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Karadeniz C., Koyuncuoğlu T., Yağmur D., Peker E., Şirvancı S., Akkiprik M., ...More

JOURNAL OF PEDIATRIC SURGERY, vol.55, no.12, pp.2797-2810, 2020 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 55 Issue: 12
• Publication Date: 2020
• Doi Number: 10.1016/j.jpedsurg.2020.02.025
• Journal Name: JOURNAL OF PEDIATRIC SURGERY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
• Page Numbers: pp.2797-2810
• Keywords: Capsaicin-sensitive afferent neurons, Tight junction proteins, Dysbiosis, Oxidative injury, NF-kappa B, TIGHT JUNCTIONS, GROWTH-FACTOR, ACETIC-ACID, MODEL, PATHOGENESIS, INFANTS, GUT, OUTCOMES, STRESS, DAMAGE
• Marmara University Affiliated: Yes

Abstract

Background and Purpose: Ongoing high mortality due to necrotizing enterocolitis (NEC) necessitates the investigation of novel treatments to improve the outcome of the affected newborns. The aim was to elucidate the potential therapeutic impact of the nesfatin-1, a peptide with anti-inflammatory and anti-apoptotic effects in several inflammatory processes, on NEC-induced newborn rats.