GASTRIC LIPID-PEROXIDATION, GLUTATHIONE AND CALCIUM-CHANNEL BLOCKERS IN THE STRESS-INDUCED ULCER MODEL IN RATS


ALICAN I., TOKER F., ARBAK S., YEGEN B. , YALCIN A., OKTAY S.

PHARMACOLOGICAL RESEARCH, vol.30, no.2, pp.123-135, 1994 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 2
  • Publication Date: 1994
  • Doi Number: 10.1016/1043-6618(94)80004-9
  • Title of Journal : PHARMACOLOGICAL RESEARCH
  • Page Numbers: pp.123-135

Abstract

The antiulcer activity of verapamil and its analogues devapamil and gallopamil was studied. All three drugs reduced cold-restraint stress-induced ulcer development. Gallopamil almost abolished gastric ulcers. Verapamil prevented the increase in gastric lipid peroxidation (LP) due to stress. On the other hand, devapamil and gallopamil increased gastric lipid peroxidation and decreased glutathione levels. This effect may be attributed to the increase in oxygen supply due to possible effective vasodilation at gastric mucosa.