Protective effect of cysteinyl leukotriene receptor antagonist montelukast in bleomycin-induced pulmonary fibrosis

Topaloglu N., OLGUN YILDIZELİ Ş., ŞENER G., LAÇİN T., Sehirli O., BOZKURTLAR E., ...Daha Fazla

TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, cilt.26, sa.4, ss.588-597, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5606/tgkdc.dergisi.2019.15149
  • Dergi Adı: TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.588-597
  • Anahtar Kelimeler: Bleomycin, collagen, glutathione, interstitial lung disease, malondialdehyde, myeloperoxidase, transforming growth factor beta 1, tumor necrosis factor-alpha, GROWTH-FACTOR-BETA, NECROSIS-FACTOR-ALPHA, MOUSE MODEL, MECHANISMS, PATHOGENESIS, COLLAGEN, INJURY, CELLS, PROLIFERATION, EXPRESSION
  • Marmara Üniversitesi Adresli: Evet

Özet

Background: This study aims to investigate the early- and late-term effects of pharmacological inhibition of cysteinyl leukotriene activity by using montelukast in bleomycin-induced inflammatory and oxidative lung injury in an animal model.