Synthesis, characterization, and biological properties of composites of hydroxyapatite and hexagonal boron nitride


ÜNAL S. , EKREN N. , Sengil A. Z. , OKTAR F. N. , Irmak S., Oral O., ...More

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, vol.106, no.6, pp.2384-2392, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 106 Issue: 6
  • Publication Date: 2018
  • Doi Number: 10.1002/jbm.b.34046
  • Title of Journal : JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
  • Page Numbers: pp.2384-2392
  • Keywords: composites, hydroxyapatite, bovine bone, hexagonal boron nitride, bioceramic, MECHANICAL-PROPERTIES, SINTERING TEMPERATURE, APATITE, NANOPARTICLES, NANOTUBES, BHA

Abstract

Hydroxyapatite (HA), obtained from bovine bones, was successfully reinforced with hexagonal boron nitrite (h-BN). h-BN/HA composites, with BN content up to 1.5 wt %, were sintered at various temperatures between 1000 and 1300 degrees C, in air. Well-sintered samples were obtained after sintering at 1200 and 1300 degrees C. The presence of h-BN contributed to dense, fine, and well-crystallized microstructure. The results of X-ray diffraction analysis and FT-IR spectroscopy showed that the produced composites comprised biphasic beta-TCP/HCA (HCA: carbonate partially substituted HA). High values of mechanical properties were achieved, namely compression strength 155 MPa for the sample 0.5% h-BN/HA and Vickers microhardness of 716 HV for the samples 1.5% h-BN/HA, both sintered at 1300 degrees C. U2OS human bone osteosarcoma proliferation and cell viability showed no adverse effect in the presence of h-BN/HA, suggesting the potential use of the produced materials as safe biomaterials in bone tissue engineering. (C) 2017 Wiley Periodicals, Inc.