Effect of High Cholesterol Diet and alpha-Tocopherol Supplementation on Endoplasmic Reticulum Stress and Apoptosis in Hippocampus Tissue

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Sozen E., Demirel-Yalciner T., Ece A., Ismicoglu A., KARTAL ÖZER N.

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, cilt.12, sa.2, ss.439-444, 2022 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.33808/clinexphealthsci.972222
  • Dergi Adı: CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.439-444
  • Anahtar Kelimeler: Hypercholesterolemia, Endoplasmic reticulum stress, Proteasome, Apoptosis, Hippocampus, UNFOLDED PROTEIN RESPONSE, VITAMIN-E, PARKINSONS-DISEASE, ALZHEIMERS-DISEASE, OXIDATIVE STRESS, FED RABBIT, RISK, MECHANISMS, PATHOLOGY, NEURONS
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective: Neurodegenerative diseases are life-threatening disorders that occur when cells in peripheral nervous system or brain lose function over time and ultimately die. Our study aimed to establish a high cholesterol fed rabbit model to investigate the status of endoplasmic reticulum (ER) stress, proteasome activity and apoptosis as well as the beneficial role of alpha-tocopherol on hippocampus.