Oxytocin protects against sepsis-induced multiple organ damage: Role of neutrophils


Iseri S., Sener G. , Saglam B., Gedik N., Ercan F. , Yegen B.

JOURNAL OF SURGICAL RESEARCH, vol.126, no.1, pp.73-81, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 126 Issue: 1
  • Publication Date: 2005
  • Doi Number: 10.1016/j.jss.2005.01.021
  • Title of Journal : JOURNAL OF SURGICAL RESEARCH
  • Page Numbers: pp.73-81
  • Keywords: oxytocin, sepsis, myeloperoxidase, glutathione, TNF-alpha, MELATONIN TREATMENT, OXIDATIVE STRESS, GROWTH-HORMONE, SEPTIC SHOCK, INFLAMMATION, RAT, INJURY, PERITONITIS, LIPOPOLYSACCHARIDE, GLUTATHIONE

Abstract

Background. Sepsis, commonly associated with enhanced generation of reactive oxygen metabolites, leads to multiple organ dysfunctions. The neurohypophyseal hormone oxytocin (OT), released during social contact, was recently shown to modulate the immune and inflammatory processes. We investigated the protective role of OT against sepsis-induced pelvic inflammation.