Relation between cholecystokinin and antral innervation in the control of gastric emptying in the rat


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Higham A., Vaillant C., Yegen B. , Thompson D., Dockray G.

GUT, vol.41, no.1, pp.24-32, 1997 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 1
  • Publication Date: 1997
  • Doi Number: 10.1136/gut.41.1.24
  • Title of Journal : GUT
  • Page Numbers: pp.24-32
  • Keywords: antral neurons, benzalkonium chloride, cholecystokinin, gastric emptying, GENE-RELATED PEPTIDE, VASOACTIVE INTESTINAL POLYPEPTIDE, BOMBESIN-LIKE, NITRIC-OXIDE, NERVE-FIBERS, GUINEA-PIG, NEURONS, IMMUNOREACTIVITY, OCTAPEPTIDE, PYLORUS

Abstract

Background-Antral motility and the hormone cholecystokinin (CCK) are major determinants of the rate of gastric emptying. The relation between CCK and antral neurons in regulating gastric emptying is uncertain. Benzalkonium chloride (BAG) causes selective lesions in gut myenteric neurons after serosal application