Ertapenem versus Standard Triple Antibiotic Therapy for the Treatment of Perforated Appendicitis in Pediatric Patients: A Prospective Randomized Trial


Dalgic N., Karadag C. A. , Bayraktar B., SANCAR M. , Kara O., Pelit S., ...More

EUROPEAN JOURNAL OF PEDIATRIC SURGERY, vol.24, no.5, pp.410-418, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 5
  • Publication Date: 2014
  • Doi Number: 10.1055/s-0033-1352524
  • Title of Journal : EUROPEAN JOURNAL OF PEDIATRIC SURGERY
  • Page Numbers: pp.410-418
  • Keywords: perforated appendicitis, children, ertapenem, bowel flora, VANCOMYCIN-RESISTANT ENTEROCOCCI, SPECTRUM BETA-LACTAMASE, GRAM-NEGATIVE BACILLI, IN-VITRO ACTIVITIES, INTRAABDOMINAL INFECTIONS, KLEBSIELLA-PNEUMONIAE, COMPLICATED APPENDICITIS, PSEUDOMONAS-AERUGINOSA, SUSCEPTIBLE ORGANISMS, INTESTINAL MICROFLORA

Abstract

Background The primary objective of this study was to compare triple therapy with ertapenem treatments in pediatric patients with perforated appendicitis, especially in terms of postoperative infectious complications. The secondary objective of this study was to assess the relative impact of therapy with ertapenem and triple antibiotic regimen on the emergence of resistant bacteria in bowel flora in the patients.