3D-printable wound patch composed of vitamin E-enriched polylactic acid scaffolds

Bayramicli İ., Nouri S., ULAĞ S., Ayran M., ŞAHİN A., GÜNDÜZ O.

MATERIALS LETTERS, vol.382, 2025 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 382
  • Publication Date: 2025
  • Doi Number: 10.1016/j.matlet.2024.137949
  • Journal Name: MATERIALS LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Keywords: Biomaterials, Poly-lactic acid, Skin tissue engineering, dressing, Vitamin E, 3D printing
  • Marmara University Affiliated: Yes

Abstract

This study focuses on the development of a 3D-printed tissue-regenerating wound coverage using Polylactic Acid (PLA) + Vitamin E. PLA, a widely-used resorbable material with established biocompatibility, is combined with two different amounts (1 capsule and 2 capsules) of Vitamin E. The mechanical, chemical, thermal, and morphological properties of the 3D-printed scaffolds were investigated during the study. The results demonstrated a homogeneous distribution of Vitamin E in the PLA scaffolds and structural integrity. The addition of Vitamin E to PLA scaffolds significantly enhanced cell viability compared to standard PLA scaffolds on both day 1 and day 3, as assessed by the MTT assay. Notably, the PLA scaffold with Vitamin E achieved 133.6 % viability on day 1, indicating improved biocompatibility and greater support for cell growth. Vitamin E release from the PLA scaffolds was achieved in 48 h.