SREBP1c silencing reduces endoplasmic reticulum stress and related apoptosis in oleic acid induced lipid accumulation

Sozen E., Demirel-Yalciner T., Demir D. D., Oznacar B., KARTAL ÖZER N.

MARMARA MEDICAL JOURNAL, cilt.34, sa.3, ss.241-247, 2021 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.5472/marumj.1009096
  • Dergi Adı: MARMARA MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.241-247
  • Anahtar Kelimeler: Lipid accumulation, SREBP1c, ER stress, Apoptosis, DE-NOVO LIPOGENESIS, ER STRESS, INSULIN ACTION, IN-VITRO, LIVER, STEATOSIS, ACTIVATION, MECHANISMS, PATHOGENESIS, EXPRESSION
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective: Sterol regulatory element binding protein 1c (SREBP1c) is one of the major transcription factors that is involved in non-alcoholic fatty liver disease (NAFLD) development by increasing hepatic fatty acid and triglyceride synthesis. Our study aimed to investigate the interaction of SREBP1c with endoplasmic reticulum (ER) stress in oleic acid (OA) induced lipid accumulation.