Impact of glucocorticoid receptor gene (NR3C1) polymorphisms in Turkish patients with metabolic syndrome


Kaya Z., Caglayan S., Akkiprik M. , Aral C., Ozisik G., Ozata M., ...More

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, vol.39, no.5, pp.557-566, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.1007/s40618-015-0409-1
  • Title of Journal : JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • Page Numbers: pp.557-566
  • Keywords: Metabolic syndrome, Glucocorticoid receptor gene, Glucocorticoid, C-REACTIVE PROTEIN, FRAGMENT-LENGTH-POLYMORPHISM, PITUITARY-ADRENAL AXIS, IN-VIVO, CHINESE POPULATION, ASSOCIATION, SENSITIVITY, STRESS, RISK, BCLI

Abstract

Background The metabolic syndrome (MetS) is characterized by a cluster of metabolic factors, including insulin resistance and type-2 diabetes, abdominal obesity, dyslipidemia, hypertension and microalbuminuria. Impaired glucocorticoid receptor (GR) activity also plays an important role in the etiology of MetS. The objective of our study is to evaluate the effects of GR gene polymorphisms (BclI, N363S, TthIII1 and ER22/23EK) in Turkish patients with MetS.