Lipid peroxidation and paraoxonase activity in nocturnal cyclic and sustained intermittent hypoxia


Okur H. K. , Pelin Z., YÜKSEL M. , YOSUNKAYA Ş.

SLEEP AND BREATHING, vol.17, no.1, pp.365-371, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.1007/s11325-012-0703-5
  • Title of Journal : SLEEP AND BREATHING
  • Page Numbers: pp.365-371
  • Keywords: Intermittent hypoxia, Obstructive sleep apnea, Chronic obstructive pulmonary disease, Paraoxonase, Lipid peroxidation, Oxidative stress, OBSTRUCTIVE SLEEP-APNEA, LOW-DENSITY-LIPOPROTEIN, 60 MM HG, PULMONARY-DISEASE, OXIDATIVE STRESS, LUNG-FUNCTION, ATHEROSCLEROSIS, ASSOCIATION, ACTIVATION, MORTALITY

Abstract

Obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) have been known to be associated with atherosclerosis and hypoxia which was suggested to have an important role in this process by the way of increased oxidative stress. In the present study, we aimed to evaluate the effects of nocturnal hypoxia pattern (intermittent versus sustained) on serum lipid peroxidation and paraoxonase (PON) activity.