Fascin expression in cholesteatoma: correlation with destruction of the ossicular chain and extent of disease.

Binnetoglu, A.; Sari, M.; Baglam, T.; Seven, Erbarut; Yumusakhuylu, ALİ; Topuz, M.; Batman, ABDULLAH

doi:10.1111/coa.12373

Fascin expression in cholesteatoma: correlation with destruction of the ossicular chain and extent of disease.

Binnetoglu A., Sari M., Baglam T., Seven E., Yumusakhuylu A. C., Topuz M. F., ...Daha Fazla

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, cilt.40, sa.4, ss.335-40, 2015 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 40 Sayı: 4
Basım Tarihi: 2015
Doi Numarası: 10.1111/coa.12373
Dergi Adı: Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.335-40
Marmara Üniversitesi Adresli: Evet

Özet

ObjectiveFascin is an actin-bundling protein found in cell membrane protrusions and increases cell motility. The expression of fascin in epithelial neoplasms has been described only recently. No data are available concerning the role of this protein in invasive cholesteatoma. Thus, we investigated the expression of fascin in cholesteatoma tissue and the relationship between fascin expression and intraoperative evaluation of the destruction of the ossicular chain and extent of disease.