European Academy of Neurology Congress 2022, Vienna, Avusturya, 25 - 29 Haziran 2022, cilt.29, ss.530-689
Background and aims: Ptosis and diplopia are frequent
presentation symptoms in the emergency rooms,
ophthalmology and neurology clinics. Most of these cases
are referred for single fiber electromyographic (SFEMG)
examination to confirm or rule out ocular myasthenia gravis
(OMG). The aim of this study is to investigate the clinical
utility of SFEMG in the assessment of patients with ocular
symptoms and signs.
Methods: The clinical and electrophysiological data of
patients with isolated ocular symptoms, who were referred
for SFEMG/jitter analysis to our laboratory for the last 3
years, were retrospectively reviewed.
Results: A total of 122 cases (78 female, 44 male) were
included in the study. In retrospective review of the followup charts, 62.3% of them were found to have nonmyasthenic disorders. Only 37.7% of the patients had the
final diagnosis of OMG. The presence of both ptosis and
diplopia, diurnal fluctuation and alternating patern were
more likely to be indicative of OMG (p<0,001). SFEMG
test was found to have a sensitivity of 80,4%, specificity of
90,8%, positive predictive value of 84.1%, and negative
predictive value of 88.5%.
Conclusion: This study confirms the diagnostic utility of
SFEMG in OMG, in concordance with the literature.
However, it draws attention to the overutilization of the test
and frequent misdiagnosis of OMG in clinical practice.
Disclosure: Authors have no financial disclosure.