Linezolid treatment of shunt-related cerebrospinal fluid infections in children Clinical article


Yilmaz A., Dalgic N., Musluman M., SANCAR M. , Colak I., Aydin Y.

JOURNAL OF NEUROSURGERY-PEDIATRICS, vol.5, no.5, pp.443-448, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 5 Issue: 5
  • Publication Date: 2010
  • Doi Number: 10.3171/2009.12.peds09421
  • Title of Journal : JOURNAL OF NEUROSURGERY-PEDIATRICS
  • Page Numbers: pp.443-448
  • Keywords: linezad, ventriculoperitoneal shunt, infection, multidrug resistance, RESISTANT ENTEROCOCCUS-FAECIUM, NERVOUS-SYSTEM INFECTIONS, STAPHYLOCOCCUS-AUREUS, BACTERIAL BIOFILMS, VANCOMYCIN, MENINGITIS, VENTRICULITIS, EXPERIENCE, MANAGEMENT, SUSCEPTIBILITY

Abstract

Object. The emergence of multidrug-resistant bacteria as a cause of ventriculoperitoneal (VP) shunt infection is a disconcerting phenomenon that often requires the use of alternative antimicrobial agents due to resistance against commonly used medications. Linezolid, a member of a new class of antimicrobial agents, has good activity against virtually all important gram-positive pathogens, including multidrug-resistant gram-positive pathogens. The object of this article is to report a single-center experience with linezolid treatment in 6 young patients with VP shunt infections caused by drug-resistant strains.