Out-of-Reference Range Thyroid-Stimulating Hormone Levels in Levothyroxine-Treated Primary Hypothyroid Patients: A Multicenter Observational Study

YAVUZ D., Yazici D., Keskin L., ATMACA A., Sancak S., Sarac F., ...More

FRONTIERS IN ENDOCRINOLOGY, vol.8, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 8
  • Publication Date: 2017
  • Doi Number: 10.3389/fendo.2017.00215
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: hypothyroidism, levothyroxine, target thyroid-stimulating hormone, thyroid-stimulating hormone, primary hypothyroidism, compliance, L-THYROXINE, PYLORI INFECTION, ABSORPTION, THERAPY, DISEASE, REPLACEMENT, PREVALENCE, COMMUNITY
  • Marmara University Affiliated: Yes


Objective: Although levothyroxine (LT4) replacement therapy for hypothyroidism has been established as safe, inexpensive and effective, many studies from different countries reported out-of-reference range thyroid-stimulating hormone (TSH) values for the hypothyroid patients under LT4 treatment. The aim of this study was to determine TSH levels of primary hypothyroid patients under LT4 treatment and to assess self-reported compliance with daily LT4 intake in tertiary care centers in Turkey.