Comparative Analysis of NF-κB in the MyD88-Mediated Pathway After Implantation of Titanium Alloy and Stainless Steel and the Role of Regulatory T Cells

Akyol S., Akgun M. Y. , Yetmez M., Hanci M., OKTAR F. N. , Ben-Nissan B.

World Neurosurgery, vol.144, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 144
  • Publication Date: 2020
  • Doi Number: 10.1016/j.wneu.2020.08.016
  • Title of Journal : World Neurosurgery
  • Keywords: Immunology, Inflammatory signal, Instrumentation, Metal implant, NE-kappa B profile, Spinal surgery, TOLL-LIKE RECEPTORS, LIPOPOLYSACCHARIDE, INFLAMMATION


© 2020 Elsevier Inc.Objective: Development of immunologically smart implants, integrated to biological systems, is a key aim to minimize the inflammatory response of the host to biomaterial implants. Methods: The aim of this study is to investigate the influence of titanium alloy and stainless steel implants on immunological responses in rats by comparative analysis of nuclear factor kappa B (NF-κB) profiles in the activation of inflammatory signaling pathways and the role of CD4+CD25+Foxp3+. Results: Both Ti alloy and stainless steel alloy group implantation affect Toll-like receptors-4 pathways and CD4+CD25+ regulatory T cells in different ways. Conclusions: Results show that NF-κB/p65 and NF-κB1/p50 possess potential as a therapeutic target in the prevention of adverse reactions to metal, especially for controlling inflammation after the implantation.