Epigenetic Mechanisms in Psychiatric Diseases and Epigenetic Therapy

KARSLI ÇEPPİOĞLU S.

DRUG DEVELOPMENT RESEARCH, cilt.77, sa.7, ss.407-413, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 77 Sayı: 7
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1002/ddr.21340
  • Dergi Adı: DRUG DEVELOPMENT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.407-413
  • Anahtar Kelimeler: psychiatric diseases, epigenetics, HDAC inhibitors, DNMT inhibitors, HISTONE DEACETYLASE INHIBITORS, DEPRESSIVE-LIKE BEHAVIOR, DNA METHYLATION, BIPOLAR DISORDER, GABAERGIC INTERNEURONS, SYNAPTIC PLASTICITY, NEUROTROPHIC FACTOR, LYSINE METHYLATION, PREFRONTAL CORTEX, MAJOR DEPRESSION
  • Marmara Üniversitesi Adresli: Evet

Özet

Epigenetic mechanisms refer covalent modification of DNA and histone proteins that control transcriptional regulation of gene expression. Epigenetic regulation is involved in the development of the nervous system and plays an important role in the pathophysiology of psychiatric disorders, including depression, bipolar disorder, and schizophrenia. Epigenetic drugs, including histone deacetylation and DNA methylation inhibitors have received increased attention for the management of psychiatric diseases. The purpose of this review is to discuss the potential of epigenetic drugs to treat these disorders and to clarify the mechanisms by which they regulate the dysfunctional genes in the brain. Drug Dev Res 77 : 407-413, 2016. (c) 2016 Wiley Periodicals, Inc.