Angiotensin-converting enzyme gene polymorphism in arrhythmogenic right ventricular dysplasia: is DD genotype helpful in predicting syncope risk?

ÖZBEN SADIÇ, BESTE; Altun, Ibrahim; Hancer, Veysel; Bilge, Ahmet; Tanrikulu, Azra; Diz-Kucukkaya, Reyhan; FAK, ALİ; Yilmaz, Ercument; Adalet, Kamil

doi:10.1177/1470320308099126

Angiotensin-converting enzyme gene polymorphism in arrhythmogenic right ventricular dysplasia: is DD genotype helpful in predicting syncope risk?

Atıf İçin Kopyala

ÖZBEN SADIÇ B., Altun I., Hancer V. S., Bilge A. K., Tanrikulu A. M., Diz-Kucukkaya R., ...Daha Fazla

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, cilt.9, sa.4, ss.215-220, 2008 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 9 Sayı: 4
Basım Tarihi: 2008
Doi Numarası: 10.1177/1470320308099126
Dergi Adı: JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.215-220
Marmara Üniversitesi Adresli: Evet

Özet

Introduction. Arrhythmogenic right ventricular dysplasia (ARVD) is a heritable disorder characterised by fibrofatty replacement of right ventricular myocytes and increased risk of ventricular arrhythmias and sudden cardiac death. Angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D)) polymorphism affects myocardial ACE levels. DD genotype favours myocardial fibrosis and is associated with malignant ventricular tachycardia. The aim of this study was to explore ACE gene polymorphism in ARVD patients.