Turkish Neonatal Society Guideline on the Diagnosis and Management of Germinal Matrix Hemorrhage-Intraventricular Hemorrhage and Related Complications

Cizmeci M. N., AKIN M. A., ÖZEK E.

TURKISH ARCHIVES OF PEDIATRICS, cilt.56, sa.5, ss.499-512, 2021 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Sayı: 5
  • Basım Tarihi: 2021
  • Doi Numarası: 10.5152/turkarchpediatr.2021.21142
  • Dergi Adı: TURKISH ARCHIVES OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.499-512
  • Anahtar Kelimeler: Germinal matrix hemorrhage, intraventricular hemorrhage, complications, POSTHEMORRHAGIC VENTRICULAR DILATATION, EXTREMELY PRETERM INFANTS, UMBILICAL-CORD MILKING, WHITE-MATTER, NEURODEVELOPMENTAL OUTCOMES, MAINTENANCE TOCOLYSIS, FIBRINOLYTIC THERAPY, LATERAL VENTRICLES, PRESSURE-PASSIVITY, CRANIAL ULTRASOUND
  • Marmara Üniversitesi Adresli: Evet

Özet

Germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH) remains an important cause of brain injury in preterm infants, and is associated with high rates of mortality and adverse neurodevelopmental outcomes, despite the recent advances in perinatal care. Close neuroimaging is recommended for both the detection of GMH-IVH and for the follow-up of serious complications, such as post-hemorrhagic ventricular dilatation (PHVD). Although the question when best to treat PHVD remains a matter of debate, recent literature on this topic shows that later timing of interventions predicted higher rates of neurodevelopmental impairment, emphasizing the importance of a well-structured neuroimaging protocol and timely interventions. In this guideline, pathophysiologic mechanisms, preventive measures, and clinical presentations of GMH-IVH and PHVD will be presented, and a neuroimaging protocol as well as an optimal treatment approach will be proposed in light of the recent literature.