EFFECTS OF HOMOCYSTEINE ON eNOS AND DDAH GENE EXPRESSION LEVELS IN PRIMARY HUMAN UMBILICAL ENDOTHELIAL CELL CULTURE

AKKİPRİK M., Cevik D., Ozer A., Emerk K.

MARMARA MEDICAL JOURNAL, cilt.20, sa.3, ss.144-149, 2007 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 3
  • Basım Tarihi: 2007
  • Dergi Adı: MARMARA MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.144-149
  • Marmara Üniversitesi Adresli: Evet

Özet

Aim: Elevated plasma homocysteine levels are independent risk factors for myocardial infarction, stroke and peripheral vascular disease. The aim of this study was to investigate effects of homocysteine on nitric oxide (NO) synthesis, bioavailability and degradation by analysis gene expression levels of endothelial nitric oxide synthase (eNOS) and dimethylarginine dimethylaminohydrolase (DDAH) and also NO levels in endothelial cell line.