Alpha linolenic acid and oleic acid additively down-regulate malignant potential and positively cross-regulate AMPK/S6 axis in OE19 and OE33 esophageal cancer cells

Moon H., Batirel S. , Mantzoros C. S.

METABOLISM-CLINICAL AND EXPERIMENTAL, vol.63, no.11, pp.1447-1454, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 11
  • Publication Date: 2014
  • Doi Number: 10.1016/j.metabol.2014.07.009
  • Page Numbers: pp.1447-1454
  • Keywords: Alpha Linolenic acid, Oleic acid, Esophageal cancer, Malignant potential, AMPK/S6 axis, ACTIVATED PROTEIN-KINASE, BREAST-CANCER, FATTY-ACIDS, SIGNALING PATHWAY, CARCINOMA, GROWTH, PROSTATE, DISEASE, LIPIDS, RISK


Objective. Both oleic acid (OA) and alpha-linolenic acid (ALA) have been proposed to down-regulate cell proliferation of prostate, breast, and bladder cancer cells. However, direct evidence that OA and/or ALA suppresses to the development of esophageal cancer has not been studied. Also, no previous studies have evaluated how OA and/or ALA regulates malignant potential (cell proliferation, migration, colony formation and adhesion) and intracellular signaling pathways, and whether their effects might be synergistic and/or additive in esophageal cancer cells has not yet been elucidated.