INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, vol.50, no.10, pp.1586-1592, 2019 (Journal Indexed in SCI)
Article / Article
Title of Journal :
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
Antiapoptotic effect, Diffuse brain injury, Mildronate, Neuroprotection, CEREBRAL-BLOOD-FLOW, ISCHEMIA-REPERFUSION INJURY, ACID OXIDATION INHIBITORS, SPINAL-CORD ISCHEMIA, GAMMA-BUTYROBETAINE, ISCHEMIA/REPERFUSION INJURY, CARNITINE BIOSYNTHESIS, SUPEROXIDE-DISMUTASE, PROTEIN EXPRESSION, DARBEPOETIN-ALPHA
Objective: Traumatic brain injury (TBI) is one of the most common preventable causes of mortality and morbidity. Inflammation, apoptosis, oxidative stress, and ischemia are some of the important pathophysiological mechanisms underlying neuronal loss after TBI. Mildronate is demonstrated to be beneficial in various experimental models of ischemic diseases via anti-inflammatory, antioxidant, and neuroprotective mechanisms. This study aimed to investigate possible antioxidant, anti-inflammatory, antiapoptotic, and neuroprotective effects of mildronate in a rat model of TBI.