The response to hepatitis B vaccine: does it differ in celiac disease?

Ertem Şahinoğlu D., Gonen I., Tanidir C., Ugras M., Yildiz A., Pehlivanoglu E., ...Daha Fazla

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, cilt.22, sa.7, ss.787-793, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 7
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1097/meg.0b013e32832e9d41
  • Dergi Adı: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.787-793
  • Anahtar Kelimeler: celiac disease, children, hepatitis B, human leukocyte antigen type, vaccine response, LONG-TERM IMMUNOGENICITY, VIRUS, HLA, NONRESPONSE, EFFICACY, RESPONSIVENESS, PROTECTION, ANTIGEN, BINDING, TRIAL
  • Marmara Üniversitesi Adresli: Evet

Özet

Objectives There is a relationship between nonresponsiveness to hepatitis B virus (HBV) vaccine and certain human leukocyte antigen (HLA) genotypes. In healthy population, 4-10% vaccine recipients fail to produce protective levels of antibodies to the HBV vaccine after standard immunization depending upon age and the presence of various underlying diseases. Celiac disease (CD) is an HLA-associated immunological disease. It has been suggested that certain HLA haplotypes which are linked to CD are associated with nonresponse to HBV vaccine as well. The aim of this study is to assess the response to HBV vaccine prospectively in a group of CD and to explore the potential link between CD and HBV vaccine nonresponse by studying shared HLA haplotypes.