Phospholipase activity of Candida albicans isolates from patients with denture stomatitis: The influence of chlorhexidine gluconate on phospholipase production

Kadir T., Gumru B., Uygun-Can B.

ARCHIVES OF ORAL BIOLOGY, cilt.52, sa.7, ss.691-696, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 7
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.archoralbio.2006.12.008
  • Dergi Adı: ARCHIVES OF ORAL BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.691-696
  • Anahtar Kelimeler: candida, denture stomatitis, phospholipase, chlorhexidine, HUMAN ORAL CAVITY, SACCHAROMYCES-CEREVISIAE, VIRULENCE FACTORS, BRIEF EXPOSURE, MOUTH RINSES, ADHERENCE, DUBLINIENSIS, ANTIMYCOTICS, INFECTIONS, RETENTION
  • Marmara Üniversitesi Adresli: Evet

Özet

Background and objectives: The extracellular phospholipases of Candida albicans are considered to play a significant role in the pathogenesis of human infections. Therefore 23 clinical oral isolates of C. albicans from patients with denture stomatitis and 22 commensal oral isolates obtained from the palatal mucosa of healthy subjects were assayed for phospholipase activity. It is generally accepted that chlorhexidine gluconate is an appropriate adjunct or an alternative to antimycotic therapy in the management of oral candidiasis. However, the intraoral concentrations of this antiseptic fluctuate considerably due to the dynamics of the oral cavity. So the second main objective of this study was to investigate the effect of brief exposure (30 min) to two sub-therapeutic concentrations (0.002% and 0.0012%) of chlorhexidine gluconate on the value of phospholipase production (Pz) of C. albicans.