Protective effect of ferulic acid on cisplatin induced nephrotoxicity in rats

Bami E., BİNGÖL ÖZAKPINAR Ö., ÖZDEMİR KUMRAL Z. N., Koroglu K., ERCAN F., Cirakli Z., ...More

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, vol.54, pp.105-111, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54
  • Publication Date: 2017
  • Doi Number: 10.1016/j.etap.2017.06.026
  • Journal Name: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.105-111
  • Keywords: Kidney, Cisplatin, Ferulic acid, Curctunin, INHIBITING RENAL INFLAMMATION, OXIDATIVE STRESS, CURCUMIN, KIDNEY, INJURY, MECHANISMS, APOPTOSIS, DAMAGE, BIOMARKER
  • Marmara University Affiliated: Yes

Abstract

This study aims to determine the potential protective effects of ferulic acid against cisplatin-induced nephrotoxicity and to compare its effect with curcumin, a well-known protective agent against cisplatin- induced toxicity in rats. Administration of cisplatin resulted in high BUN (Blood Urea Nitrogen), creatinine, MDA (Malondialdehyde), MPO (Myeloperoxidase), TOS (Total Oxidative Status), PtNT (Protein Nitrotyrosine) levels (p < 0.05). Histological observations showed abnormal morphology of kidney; in addition with appearance of TUNEL positive cells indicating apoptosis in cisplatin administered group. HO-1 (Heme Oxygenase-1) levels measured by RT-PCR (Real Time Polymerase Chain Reaction), and TAS (Total Antioxidative Status) revealed antioxidant depletion due to cisplatin toxicity in animals (p < 0.05). All parameters showed improvement in groups treated with ferulic acid (p < 0.05). Ferulic acid treatment was found significant in preventing oxidative stress, increasing antioxidative status and regaining histological parameters to normal, indicating nephroprotective and antioxidant effects of this phenolic compound.