Microbial transformation of Astragalus sapogenins using Cunninghamella blakesleeana NRRL 1369 and Glomerella fusarioides ATCC 9552

Bedir E., KULA C., Oner O., Altas M., Tag O., ÖNGEN ÖZGEN G.

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, vol.115, pp.29-34, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 115
  • Publication Date: 2015
  • Doi Number: 10.1016/j.molcatb.2015.01.013
  • Journal Name: JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.29-34
  • Keywords: Astragalus, Microbial transformation, Cycloastragenol, Cyclocanthogenol, Astragenol, BIOTRANSFORMATION, ACID, CYCLOASTRAGENOL, TRITERPENOIDS
  • Marmara University Affiliated: Yes

Abstract

The microbial transformation of Astragalus sp. derived sapogenins, namely cycloastragenol, astragenol and cyclocanthogenol, by Cunninghamella blakesleeana NRRL 1369 and Glomerella fusarioides ATCC 9552 were investigated. The unique enzyme system of both fungi resulted hydroxylation, cyclization, dehydrogenation and oxidation reactions. Structures of the new metabolites were elucidated by 1-D (H-1, C-13, NOESY), 2-D NMR (DQF-COSY, HMBC, HMQC, NOESY) and HR-MS analyses. (C) 2015 Elsevier B.V. All rights reserved.