Potential Effect of 1,25 Dihydroxyvitamin D<sub>3</sub> on Thioacetamide-Induced Hepatotoxicity in Rats.


Özdemir-Kumral Z. N. , Erkek B., Karakuş B., Almacı M., Fathi R., Yüksel M. , ...More

The Journal of surgical research, vol.243, pp.165-172, 2019 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 243
  • Publication Date: 2019
  • Doi Number: 10.1016/j.jss.2019.05.020
  • Title of Journal : The Journal of surgical research
  • Page Numbers: pp.165-172
  • Keywords: Apoptosis, 1,25(OH)(2)D-3, Hepatotoxicity, Oxidative stress, Rat, Thioacetamide, INDUCED LIVER-INJURY, VITAMIN-D, HEPATIC-ENCEPHALOPATHY, NITRIC-OXIDE, OXIDATIVE STRESS, APOPTOSIS, PROTECTS, INFLAMMATION, INVOLVEMENT, MODELS

Abstract

Background: 1,25 Dihydroxyvitamin D-3 (1,25(OH)(2)D-3) modulates inflammation and immune responses. Deficiency of 1,25(OH)(2)D-3 was found to be associated with the risk of cancer, cardiovascular disease, osteoarthritis, infections, and autoimmune diseases. This study evaluated the effect of 1,25 dihydroxyvitamin D-3 1,25(OH)(2)D-3 on thioacetamide (TAA)-induced acute liver injury in rats.