Synthesis and Biological Activity of N-(arylsulfonyl) Valine Hydrazones and Assistance of NMR Spectroscopy for Definitive 3D Structure

ŞENKARDEŞ S., TATAR E., Nepravishta R., Cela D., Paci M., Ozakpinar Ö., ...More

LETTERS IN DRUG DESIGN & DISCOVERY, vol.16, no.9, pp.974-983, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 9
  • Publication Date: 2019
  • Doi Number: 10.2174/1570180815666180810120609
  • Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.974-983
  • Keywords: Acylhydrazones, anti-HIV activity, antileukemia activity, 2D-NMR spectroscopy, 3D structure, L-valine, microwave assisted synthesis, ACYLHYDRAZONE DERIVATIVES, ANTITUBERCULAR ACTIVITY, HCK INHIBITORS, CANCER, IDENTIFICATION, ANTICANCER, APOPTOSIS, REPLICATION
  • Marmara University Affiliated: Yes

Abstract

Background: Hydrazide-hydrazones constitute an important class of compounds for new drug development. In this study, a series of 39 new acylhydrazones (3-41), derived from (2S)-3-methyl-2-[[( 4-methylphenyl)sulfonyl]amino]butanoic acid hydrazide were synthesized with further aim to achieve biologically active acylhydrazones carrying an amino acid side chain.