Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism

Weger M., Weger B. D., Goerling B., Poschet G., Yildiz M., Hell R., ...Daha Fazla

EBIOMEDICINE, cilt.36, ss.376-389, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.ebiom.2018.09.024
  • Dergi Adı: EBIOMEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.376-389
  • Anahtar Kelimeler: Zebrafish, Ferredoxin, Adrenal insufficiency, Oxidative stress, Purine metabolism, GENE-EXPRESSION, ZEBRAFISH, RECEPTOR, BIOSYNTHESIS, MODEL, STEROIDOGENESIS, IDENTIFICATION, MORPHOLOGY, REGULATOR, ENZYME
  • Marmara Üniversitesi Adresli: Evet

Özet

Background: Deficient glucocorticoid biosynthesis leading to adrenal insufficiency is life-threatening and is associated with significant co-morbidities. The affected pathways underlying the pathophysiology of co-morbidities due to glucocorticoid deficiency remain poorly understood and require further investigation.