99m-Tc-MDP-scintimammography in the evaluation of breast masses or tumor angiogenesis

Turhal N., Dane F., Dede F., Gumus M., Yumuk P. F., Cakalagaoglu F., ...More

ANTICANCER RESEARCH, vol.24, no.3B, pp.1999-2006, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 3B
  • Publication Date: 2004
  • Journal Name: ANTICANCER RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1999-2006
  • Keywords: breast cancer, mammography, technetium Tc-99m-medronate, VEGF, ENDOTHELIAL GROWTH-FACTOR, POSITIVE PREDICTIVE-VALUE, TC-99M METHOXYISOBUTYLISONITRILE, MAMMOGRAPHIC FEATURES, CANCER, SCINTIMAMMOGRAPHY, TC-99M-SESTAMIBI, SCINTIGRAPHY, MECHANISMS, CARCINOMA
  • Marmara University Affiliated: Yes

Abstract

Background: Vascular endothelial growth factor (VEGF) is a prognostic factor in breast cancer. One of the mechanisms of extra-skeletal uptake of Tc-99m-methylenediphosphonate (MDP) is suggested to be tumor vascularity. We studied the correlation between MDP uptake and VEGF and compared the diagnostic accuracy of mammography versus MDP-scintimammography(MDP-S). Materials and Methods: Fifty-four patients with suspicion of breast cancer were evaluated. Breast images were collected 5-10 minutes after injection of Tc-99m-MDP prior to biopsy. Tissue slides were stained using a rabbit-polyclonal anti-VEGE Results: MDP-S showed a diagnostic accuracy of 83.3% in BIRADS category 4 lesions. Four out of 23 benign lesions were false-positive. The tumor to background (TM/BG) ratio of early images of MDP-S was correlated with VEGF staining (p: 0.014) and with tumor size (p: 0.006). Conclusion: Early images of Tc-99m-MDP-S may satisfactorily identify cancers with increased neovascularization. MDP-S seems to be an accurate imaging modality, especially in BIRADS category 4 lesions.