Silymarin, the antioxidant component of Silybum marianum, protects against burn-induced oxidative skin injury

Toklu H. Z. , Tunah-Akbay T. , Erkani G., Yuksel M. , Ercan F. , Sener G.

Burns, vol.33, no.7, pp.908-916, 2007 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 7
  • Publication Date: 2007
  • Doi Number: 10.1016/j.burns.2006.10.407
  • Title of Journal : Burns
  • Page Numbers: pp.908-916
  • Keywords: Silymarin, burn skin, thermal, oxidative, injury, THERMAL-INJURY, ORGAN DAMAGE, RAT MODEL, LIPID-PEROXIDATION, REACTIVE OXYGEN, STRESS, INHIBITION, MELATONIN, BLOOD, STAGE

Abstract

Background: Despite recent advances, severe burn is one of the most common problems faced in the emergency room. Major thermal injury induces the activation of an inflammatory cascade resulting in local tissue damage, to contribute to the development of subsequent damage of multiple organs distant from the original burn wound.