Ghrelin against alendronate-induced gastric damage in rats

Iseri S., Sener G. , Yuksel M., Contuk G., Cetinel S., Gedik N., ...More

JOURNAL OF ENDOCRINOLOGY, vol.187, no.3, pp.399-406, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 187 Issue: 3
  • Publication Date: 2005
  • Doi Number: 10.1677/joe.1.06432
  • Page Numbers: pp.399-406


Alendronate sodium, a primary amino bisphosphonate, is widely used in the treatment of various diseases that are associated with bone resorption, such as postmenopausal osteoporosis and Paget's disease of bone. Although the adverse effects of biphosphonates on the gastrointestinal system have been demonstrated in experimental and clinical studies, the exact mechanisms underlying this damage are not clear yet. Ghrelin, a 28 amino acid peptide produced predominantly by the stomach, was shown to exert a potent protective action on the stomach of rats exposed to ethanol or stress.